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This dichotomy might be due to differential basal metabolism and redox status

(2009) 297:E135865

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for 2 weeks, on happiness and general wellbeing scores, but not on energy, sleep or appetite

The 2,2-dimethyl substitution pattern on this ring occupies a lipophilic sub-pocket between TM2 and TM3 that is highly conserved in the GLP-1 receptor but differs in related class B GPCRs such as the glucagon and GIP receptors