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From what I can tell from other comments around the web, its possibly an allergic reaction allergic conjunctivitis and some people have experienced relief with Benadryl and/or steroids, but havent tried either

Ellenbogen, Richard

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Getting Used To It: Your body might get a bit too used to them, and you might need to shake things up with your dose

Absorption differences: injection vs topical Subcutaneous injection absorption: Rapid absorption into bloodstream Peak plasma concentration: 15-30 minutes 80-90% bioavailability Reaches target tissues quickly Systemic distribution Topical application absorption: Slower penetration through skin barrier Peak tissue concentration: 1-3 hours 5-15% bioavailability (most doesn't penetrate) Primarily local effects (skin where applied) Minimal systemic exposure Absorption comparison table: Why injection more effective: Direct systemic delivery Reaches all tissues Predictable dosing Lower total dose needed Better for body-wide effects When topical makes sense: Face/neck cosmetic use only Avoiding injections Already using skincare routine Combining both approaches (injection + topical) See our GHK-Cu 50mg copper peptide dosage guide for injection protocols