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In contrast, we observed that the decreased levels of metabolites such as L-tryptophan and sphingosine 1-phosphate were negatively correlated with changes in the levels of TNF- and IL-17, but positively correlated with reduced levels of chemokines, such as MIP-1 and IL-8 ( Figure 6 )

The results also showed, relative to 1,200 mcg per day, only a small decline in benefit was seen at 800 mcg per day, and no additional benefit occurred with higher doses

It plays a critical role in transporting long-chain fatty acids into mitochondria for beta-oxidation, an essential pathway for energy production (Bieber 1988

DAMBSKA, M., IWANOWSKI, L., & KOZLOWSKI, P