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Limitations: It has relatively low sensitivity and is not suitable for samples with strong antibacterial properties

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the diagnosis and management portions of the algorithm (see Figure 1), therefore, are provided as Clinical Principles or as Expert Opinion with consensus achieved using a modified Delphi technique if differences of opinion emerged

Proper dosing requires slow titration to maximum tolerated doses, typically semaglutide 2.4mg weekly plus cagrilintide 2.4mg weekly, though conservative approaches using lower maintenance doses work well for many

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