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Data showed that GLP-1 significantly increased PI3K, Akt, and mammalian target of rapamycin (mTOR) phosphorylation without inducing the expression of PI3K, Akt, or mTOR

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Tirzepatide (a GLP-1R/GIPR dual agonist), licensed by the MHRA as Mounjaro for type 2 diabetes and, subject to NICE guidance, for weight management in adults with obesity, achieved mean weight reductions of up to approximately 22% in the SURMOUNT-1 trial (NEJM 2022) a notable improvement over GLP-1R monotherapy

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The results showed that the overexpression of ATP6AP1L gene with pcDNA3.1-GST DAF -ATP6AP1L and pcDNA3.1-GST CEAM7 -ATP6AP1L could significantly inhibit the proliferation of K-562 cells compared with the control cells transfected with empty vectors, pcDNA3.1-GST DAF, and pcDNA3.1-GST CEAM7 , respectively