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Small but statistically significant increases in lactate levels (up to 2-fold) were observed in a few animals at approximately the clinical exposure

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doi: 10.3390/ijms232416142 59 Chung WJPYJeonCHJungJWKoKPChoiSJ

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Glucagon Receptor Activation The glucagon receptor component represents the unique addition in retatrutide compared to dual agonists, providing effects specifically designed to enhance energy expenditure and fat oxidation: glucagon powerfully increases energy expenditure through thermogenic effects, boosting metabolic rate and caloric burning