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"In cases where glutathione demands are high, or there are genetics inhibit glutathione production, glutathione supplementation is often very effective." Taking glutathione itself is problematic because it is a peptide, and peptides break down in the digestive system

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Mitochondrial permeability transition [MPT] has also been shown to be important in diclofenac-induced liver injury, resulting in generation of reactive oxygen species, mitochondrial swelling and oxidation of NADP and protein thiols [144]

High glutathione levels help the liver efficiently detoxify chemicals, heavy metals, and metabolic waste