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SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin

Additionally, dysregulation in the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway further accentuates the demand for glutamine, driving an accelerated flux through the tricarboxylic acid (TCA) cycle to fuel the biosynthetic requirements of rapidly proliferating cancer cells [31]

The proposed aspects of vitamin E including inhibiting cell proliferation, cell adhesion, and protein kinase C activity, improving immunity, and modulating anti-angiogenic and antioxidation properties [49]