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monitor patients for the emergence or worsening of depression, suicidal thoughts or behavior, and any unusual changes in moods or behaviors

While preliminary studies suggest Dihexa is generally safe with minimal adverse reactions, it's important to note that long-term clinical data is limited

By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects

Studies assess dose-response relationships, secretion timing, and pulsatile patterns that mimic natural signaling

Neurotherapeutics 18, 252264