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While these short-term dose-response assays assess the cytotoxic effect of APR-246, we were also interested in the potential cytostatic effects of APR-246

In addition, technologies such as RNA sequencing, and spatial transcriptomics may improve our understanding of the molecular identities of different cell types in the brain (208) which can pave the way for designing more efficient drug delivery systems that are tailored to specific states of disease

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Result: reduction of chronic low-grade inflammation in tissues