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Genetics, hormones, and health determine when growth weakens or stops in certain areas

Hence, contrary to the expectation that hematopoietic progenitors would be geno-protected throughout life, we found that progenitor cells from aged killifish carry higher levels of DNA damage compared to all other cell types in the hematopoietic organ, as recently shown in aged mammalian HSCs 77,78 , and to some extent, in aged-adult humans 79

Notably, many if not most, gains of potentially detrimental effects come about through the loss or malfunction of physiological astrocytic processes, rather than through the activation of pre-programmed and intentionally toxic mechanisms

Over time, this helps reduce the appearance of pigmentation and contributes to a brighter, more refreshed complexion

doi: 10.1038/nrendo.2018.18 37 ChakerLRazviSBensenorIMAziziFPearceENPeetersRP