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In our systematic review and meta-analysis evaluating the clinical efficacy and safety of combinations of DPP-4 inhibitors and SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes, the combination of an SGLT2 inhibitor and a DPP-4 inhibitor showed a greater reduction in HbA1c (weighted mean difference, 0.6%), fasting plasma glucose, and 2-hour postprandial plasma glucose levels than the combination of a placebo with a DPP-4 inhibitor [47]

Potent retinoids may also need timing separation, though some users successfully alternate these ingredients on different evenings

GLP-1s can be used in people with type 2 diabetes to help regulate blood glucose

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Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet