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No patients had developed cirrhosis

C.PoderosoJ

Muscle contractions from mechanical loading induce microtrauma in muscle fibers, resulting in the rupture of the extracellular matrix, basal lamina, and sarcolemma, in addition to the alteration of calcium homeostasis, which promotes changes in the cell membrane structure and permeability [48, 49]

We further analyzed the correlation between ADP increase and lanifibranor for 1) histological features of NASH severity, and 2) biomarkers of active NASH and fibrosis

In addition, rescue experiments showed that DDX11-AS1 could accelerate HCC progression via upregulating its downstream gene carbonic anhydrase IX (CA9)