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Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Mohammadpour, H., MacDonald, C

Recently, ground-breaking studies conducted in OVX models show proof-of-principle that microbiome-targeted therapeutic modalities can be leveraged to successfully inhibit peripheral 5HT biosynthesis and ameliorate estrogen-deficiency-induced bone loss, along with concomitant modulation of neurobehavioral functions (300, 301)

Infertility affects one in six couples who are trying to conceive and in at least half of all cases of infertility, a male factor is a contributing cause

Yet a critical question emerges: can GLP-1 actually cause weight gain in certain individuals or circumstances