They also found that ROS damage affected the nucleus of the sperm causing DNA damage which could be transmitted to the next generation and be responsible for increased disease susceptibility in offspring
Subject of Research : Glutathione transport regulation and redox homeostasis in the endoplasmic reticulum Article Title : SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis News Publication Date : April 17, 2026 Web References : 10.1038/s41556-026-01922-y Image Credits : Lori Chertoff / The Rockefeller University Keywords : Antioxidants, Endoplasmic reticulum, Protein folding, Redox homeostasis, Glutathione transport, SLC33A1, Neurodegeneration, Cancer, Mitochondria, Cellular metabolism, Molecular transporters Tags: cancer and protein foldingcellular redox regulationdisulfide bond formation in proteinsendoplasmic reticulum redox homeostasisER protein maturation and traffickingglutathione role in protein foldingliposome-based assay for protein studyneurodegenerative disorder mechanismsoxidative environment in ERoxidized glutathione (GSSG) transportprotein misfolding diseasesSLC33A1 transporter function
Glutathione neutralises these and further protects your cells from damage
Antibodies that detect both GSH and GSSG have been used to label glutathione in several subcellular compartments (Zechmann et al., 2007, 2008
White, P
