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It means that changing the behavior and function of TAMs by manipulating their polarization is being explored as a potential new strategy to treat GBM(Van Dalen et al

Phase I and Phase II detoxification are two stages of the bodys natural process for breaking down and eliminating potentially harmful substances, including drugs, toxins, and metabolic waste products

10.1073/pnas.0902380106 18 HondorpE

Studies have examined its interaction with growth factor pathways, particularly the FAK-paxillin signaling cascade, which plays a role in cell migration and tissue remodeling