For vascular dementia, the 2019 Cochrane review pooled six trials and 597 patients and was more encouraging on benefit: a moderate improvement in cognition, a standardized mean difference of 0.36 (0.13 to 0.58), and a benefit on global clinical function, a risk ratio of 2.69 (1.82 to 3.98) (Cui et al., Cochrane 2019)
31.5% on placebo 69.1% achieved 15% weight loss, vs
This can trigger symptoms of orthostatic intolerance, so patients avoid exercise, which makes their symptoms worse, leading to more physical inactivity
Safe to say, semaglutide has recently gained a place in the Hollywood Bible and its here to stay
1 Substantial progress has been made over the past decade in the pharmacological management of T2D, 2,3 and recently also obesity