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Histamine lives inside and outside of cells, and DAO is needed for proper histamine control and balance

ML models, trained on extensive in vitro and in vivo datasets, can anticipate cellular uptake, toxicity profiles, and biodistribution with increasing accuracy [234]

Moreover, the activation of Sirtuin-1 can promote Parkin to translocate from cytosol into OMM, while inhibition of Sirtuin-1 reverses these effects (Gao et al., 2020b)