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To view a copy of this license, visit About this article Cite this article Benedict, C., Barclay, J., Ott, V

Corticosteroids promote: Fat redistribution , causing central (truncal) obesity and the characteristic "cushingoid" appearance with prolonged use Fluid retention , leading to weight gain that may not reflect true fat accumulation but can be discouraging Muscle protein breakdown , reducing lean body mass and potentially lowering metabolic rate Insulin resistance , making weight loss more difficult The magnitude of these effects is generally dose- and duration-dependent

This allows for precise, data-driven care rather than a one-size-fits-all approach

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies

10.1093/jn/131.9.2515S 147