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Most individuals can continue treatment comfortably with a few evidence-based adjustments, such as: Encourage a gradual dose titration

Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38

The trade-off is randomization: participants may be assigned to placebo or a lower dose arm, and the protocol imposes constraints on concurrent medications and lifestyle modifications that may not reflect individual patient circumstances

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