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Recently, STEP6 phase IIIa RCT assessed the effect of semaglutide 2.4 and 1.7 mg in an east Asian population (Fig

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About 30-40% of patients in the Cleveland Clinic series didnt see meaningful additional loss with phentermine addition

At 52 weeks, the semaglutide group showed a statistically significant reduction in areal bone mineral density at the total hip (estimated treatment difference: -0.020 g/cm, p = 0.001, equating to approximately 2.6% loss) and at the lumbar spine (ETD: -0.018 g/cm, p = 0.007, approximately 2.1% loss)

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