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Conversely, improving metabolic parameters often restores ovulation and fertility
Tirzepatide is approved for moderate to severe obstructive sleep apnea in adults with obesity
The DMH GLP-1R expressing cells are known to be predominantly GABAergic, while a smaller percentage of the population do express vesicular glutamate transporter 2 (VGLUT2) mRNA [68]
Patients should prioritize protein intake to preserve lean body mass during weight loss, aiming for 1.0-1.5 grams per kilogram of ideal body weight daily (lower for those with chronic kidney disease), distributed across meals
But the insulin sensitization effects of tirzepatide likely contribute independently, since improvements in hormonal markers sometimes precede significant weight change
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