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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

10.3892/etm.2011.382 22 KirkhamP.BarnesP

J Pharmacol Exp Ther 2016;359:452-9.ArticlePubMedPMC 3

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