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Safety Considerations and Provider-Guided Decision Framework Contraindications to either agent include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe gastroparesis, active pancreatitis, or acute kidney injury

And, in fact, GLP-1 receptor agonists like semaglutide have been shown to have anti-inflammatory properties that could be helpful for people with osteoarthritis

Research is still at an early stage

GLP-1 increases -cell mass in rodents and has also been suggested to increase -cell function in humans following bariatric surgery (80)

Allergic Reactions: Though rare, some individuals may experience an allergic reaction to Botox