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In the computational study, no support was found for the hypothesis that a water molecule could serve as an alternative to Tyr9 as a proton donor ( 1 loss of binding energy due to the absence of the glycine residue

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Additionally, its mild pH and reduced enzymatic degradation contribute to its suitability as an ideal route for drug delivery (Teng et al., 2022) pass effects refer to the initial metabolic processing of drugs in the intestinal wall or liver following oral administration, which significantly reduce the drugs bioavailability, thereby diminishing its therapeutic efficacy