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This dual mechanism is one reason peptide therapy is being explored more aggressively in men who do not respond adequately to first-line treatments

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Individuals with a Personal or Family History of Medullary Thyroid Carcinoma (MTC) One of the most critical precautions is avoiding semaglutide in people who have a personal or family history of medullary thyroid carcinoma (a rare type of thyroid cancer)

Additionally, in-vitro assays do not account for metabolism, distribution, or the complex physiological environment in which the peptide must function