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Unpredictable pharmacology : The dose-response relationship for both efficacy and safety has not been characterised at very low doses, creating uncertainty about what effectsbeneficial or harmfulmight occur
Obesity: definition, comorbidities, causes, and burden
Indeed, both in rodents and humans, GLP-1 infusion increased fractional sodium excretion [20], which has been linked to the finding that sodium is more rapidly excreted following an oral versus equivalent IV sodium load in a number of experimental studies in healthy individuals, independent of factors such as atrial natriuretic peptide (ANP) and aldosterone [22]
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