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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

Certain peptides may help regulate hunger signals, improve feelings of fullness, or support metabolic function as part of a medically supervised wellness plan.

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Fehmann HC & Habener JF., 1991