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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

Drugs such as liraglutide, semaglutide, dulaglutide, and the dual GLP-1/GIP receptor agonist tirzepatide demonstrate robust efficacy for weight reduction and glycemic optimization

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Blood samples of the dementia patients (age, 7588 y) diagnosed and hospitalized at the National Hospital Organization Ryukyu Hospital, Kin-town, Okinawa were obtained from each patient after informed consent (see Materials and Methods)