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Tirzepatide through reduced food and fluid intake (from appetite suppression) and GI effects (nausea, vomiting)

store the lyophilised solid at -20C, dry and protected from light, and hold any reconstituted solution at 2-8C

When you add tirzepatide, this schedule needs to become significantly more frequent, at least temporarily

Acknowledgements The authors would like to acknowledge the Virus testing laboratory facility under RKVY, STI HUB laboratory facility, Niche Area of Excellence (NAE) facility and Department of Biochemistry of Uttar Banga Krishi Viswavidyalaya, Pundibari, Cooch Behar, West Bengal, India for necessary instrumentation support

Trial duration was 80 weeks, with a pre-specified blinded extension to 104 weeks for a subset