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Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered

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[117] In 1990, Kennedy assisted indigenous Pehuenches in Chile in a partially successful campaign to stop the construction of a series of dams on Chile's iconic Biobo River

Tzang 2025 (18 RCTs): overweight/obesity regains +5.63 kg while type 2 diabetes regains +2.03 kg but rebounds harder on blood-sugar control (HbA1c +0.65 vs +0.25%)