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Only a small percentage of patients experience it during the initial phases and after dose escalation

Results vary based on lifestyle changes, diet, and activity levels, and its often prescribed alongside behavior changes

These findings would explain one of the mechanisms by which semaglutide reduces cardiovascular events

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387 The SURPASS-5 trial, a 40-week study that enrolled 475 individuals with type 2 diabetes, examined the addition of tirzepatide (5 mg, 10 mg, or 15 mg once weekly) to insulin compared with insulin alone in patients treated with or without metformin