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MDD ranks among the top five disabling disorders globally [488], leading not only to mental health challenges but also to serious physical health risks, such as cardiovascular disease, stroke, and metabolic disorders [489, 490]

Lancet 1998;352:837853 [PubMed] [Google Scholar] 2.UK Prospective Diabetes Study (UKPDS) Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

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[16] Moreover, there is a hypothesis that GHK-Cu might reduce the release of iron from ferritin