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These dysesthesia events were generally mild and rarely led to treatment discontinuation

Positive Contracts signed with CRO to conduct Human Pilot Study #7 Study uses 5-week, three-arm parallel design to assess safety and PK First-time use of a DHT-sema oral tablet formulation First multi-week human evaluation of DHT-sema formulations containing SNAC Study fully funded from existing corporate resources Negative Independent ethics approval is still pending before patient recruitment No PK, safety, or efficacy results available yet from this study Prior DHT-sema studies were single-dose, limiting comparative multi-dose data News Market Reaction LEXX On the day this news was published, LEXX gained 11.04% , reflecting a significant positive market reaction

N., Wharton, S., Connery, L., Alves, B.,

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Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells