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demonstrated that QE reversed the inhibition of transcription factor EB (TFEB) nuclear translocation incited by ethanol and exhibited similar effect to Torin 1 mTOR activity inhibitor) which could promote TFEB nuclear translocation, indicating that QE could alleviate chronic ethanol consumption induced liver injury and autophagic flux suppression by regulating mTOR-TFEB pathway (Li et al., 2019)
Injectable administration bypasses gut enzymes and first-pass metabolism, enabling more predictable pharmacokinetics
Cyanocobalamin taken sublingually still requires conversion after absorption
Rhonda: full knockout
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