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In particular, GLP-1 analogues have shown direct effects on the plasticity of the pancreatic islet in both normal glucose tolerance and throughout the whole spectrum of alterations leading to overt diabetes [7]

For patients with symptoms, A1c greater or equal than 10% or blood glucose greater or equal than 300 mg/dL, combined injectable therapy should be considered, including basal insulin plus bolus insulin or GLP-1 RA or premixed insulin

Unlike some medications that require strict timing around meals or specific hours of the day, tirzepatide offers a significant amount of flexibility

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