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doi: 10.1001/jama.1964.03060260063027

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In KRAS/LKB1-mutant lung cancer cells, CPS1 maintains the pyrimidine pool and DNA synthesis, and CPS1 expression negatively correlates with LKB1 in human NSCLC.CPS1 enables an unconventional pathway of nitrogen influx from ammonia to pyrimidines, and loss of CPS1 decreases the pyrimidine-to-purine ratio, impairs S-phase progression and induces DNA polymerase arrest and DNA damage(Kim et al

Investigators studying related biological processes can use these compounds within established research frameworks while complying with applicable regulations