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It plays a role in wound healing, skin regeneration, and reducing inflammation

By targeting the stubborn, pro-inflammatory senescent cells that accumulate with age, FOXO4-DRI offers the possibility of clearing the cellular garbage that impedes regeneration, contributes to chronic disease and ageing decline

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It is expressed in both central and peripheral tissues and has been implicated in the regulation of food intake, lipid metabolism, and body weight ( In animal models, spexin administration reduces food intake, suppresses adipogenesis, and improves lipid profiles