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3.3 Ruthenium compounds Cisplatin and other platinum(II)-based antitumor drugs are widely recognised for the treatment of various types of cancer, primarily ovarian, testicular, and lung cancer

Current gene therapy research aims to target, for example, upstream targets of the GSH system or molecules associated with it (such as Nrf2, GPX, SLC7A11), genes aberrantly expressed in myocardial injury, and noncoding RNAs regulating mRNA transcription [76, 202, 250253]

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X

Its unique tripeptide structure, including the N-terminal glutamyl residue linked via a -glutamyl peptide bond, provides for specificity in GSH transferase enzymes

The future of antioxidant therapy in DM lies in overcoming the limitations of broad-spectrum approaches by developing targeted, personalized, and mechanism-based interventions that address the nuanced role of OS in disease progression