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Another systematic review and network meta-analysis concluded that PRP was the most effective injectable treatment for knee OA compared to corticosteroids and HA (PMID: 35581332)

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10.3 Perspectives: from a single drug to an adaptive precision-care paradigm Future progress in this field will depend not only on more effective agents, but also on higher-quality reproductive evidence and better integration of metabolic, reproductive, and safety endpoints into clinical pathway design

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After the initial adaptation phase, the second and third months are typically where the momentum becomes undeniable