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10.3389/fmats.2018.00015 44

Synovitisthe swelling of the synovial membraneserves as the front line, where fibroblasts and macrophages swell the ranks, releasing a cytokine storm, in RA, TNF-, IL-6, and harvesting oxidative stress characters all work together as partners in crime to compound and aggravate the situation on the cellular level, as well as at the patient level [5]

Our findings suggest that some lymphoid cells accumulate in G 0 /G 1 or G 2 /M, while others experience minimal alteration in cell cycle distribution

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