For academic investigative sites that did not receive a waiver to use the central IRB, full board approval was obtained from the respective governing IRBs, and documentation of approval was submitted to CorEvitas, LLC, prior to the initiation of any study procedures
Sequential versus simultaneous initiation : Many clinicians prefer establishing tirzepatide tolerance and efficacy before adding other therapies, allowing clearer attribution of benefits and adverse effects
The warning states that this drug has caused thyroid C-cell tumors in animal studies
A great time to start the conversation is 2 years before trying to conceive, asking, how do I optimize my health for this pregnancy I'm planning for in the near future? In my dream world, everybody would have that conversation much earlier. Amato said clinicians must carefully counsel patients about the risks and benefits of the drug class, particularly for anyone who struggles with infertility and has irregular menstrual cycles
Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic
