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30-50% of patients experience CIPN with low dose regimens but at higher doses as many as 90% of patients experience neuropathy making it an important dose limiting toxicity ( Oxaliplatin, a third-generation platinum compound, is one of the most commonly used chemotherapeutic agents for treating colorectal cancer (CRC) ( CRC is now the third most common cancer in the UK and the second most common in males aged 45 to 74 years and females aged 45 to 54 years ( Three systematic reviews have previously been published examining the evidence for the utility of pharmacological interventions in preventing incidence of peripheral neuropathy induced by chemotherapy agents

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