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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Yussif NM, Zayed SO, Hasan SA, Sadek SS

544 articles screened, 36 included (35 preclinical, 1 clinical): PMC12313605 2025 narrative review Katzman BM et al

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The treatment follows a gradual dose escalation schedule over 16 weeks (0.250.51.01.72.4 mg weekly), with the option to delay escalation or maintain at 1.7 mg if the higher dose is not tolerated