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However, in a murine model, knockout of glucagon genes originating from the bowel elicited no increase in food intake, and thus appetite suppression is attributed to GLP-1 produced within the CNS [112]

39:1115-1122 [PubMed: 27289124] 183

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The medication slows gastric emptyingthe rate at which food moves from the stomach into the small intestinewhich can create sensations of fullness, bloating, and nausea