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Multiple clinical trials show that FMT is superior to placebo for inducing clinical remission in active UC (Paramsothy et al., 2019), although outcomes are influenced by donor selection, delivery route, and the patient's baseline microbiota (Pinto et al., 2025)

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The answer starts with observations made by Bayliss and Starling in 1902--the duo ground up intestinal tissue, and administered these crude extracts to animals