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Its anti-inflammatory effect appears to be largely independent of the melanocortin receptors and instead depends on the intestinal di/tripeptide transporter PepT1, which actively imports KPV into epithelial and immune cells where it can inhibit NF-B signaling and dampen production of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

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Rosenlund, J.W

Studies have found that people who don't eat as much meat don't metabolize L-carnitine as well, but those who eat a lot of it have tons of the bacteria that turn it into TMAO