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The combination of a levonorgestrel-releasing intrauterine device (LNG-IUD), metformin, and liraglutide has been shown to safely and effectively improve endometrial hyperplasia in obese patients, as well as promote the regression of early-stage endometrial cancer [41]

In theory , this means that the GLP-1s could still support weight loss, blood sugar management, and more, but to a lesser extent, says Jess DeGore, RD, a registered dietitian and diabetes expert

Clinical trials show tirzepatide has a lower burping rate (approximately 4% vs 7%) compared to semaglutide at weight-loss doses

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