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While Vitamin C is a potent immunity enhancer, it is also known to improve collagen synthesis in the body

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These epigenetic alterations, mediated by p53 signaling and subsequent transcription of PPAR, led to increased expression of PD-L1 and secretion of IL-10 and TGF, which restrained CD8 + T cells activation [88]

[DOI] [PubMed] [Google Scholar] 297.Gonzlez-Hedstrm D., de la Fuente-Fernndez M., Priego T., Martn A., Amor S., Lpez-Caldern A., Inarejos-Garca A., Garca-Villaln .L., Granado M

In addition, sustained arginine deprivation in Argininosuccinate Synthase 1 (ASS1)-deficient melanoma and breast tumor cells promotes autophagy, but, in this scenario, autophagy is associated with tumor cells death [95, 96]