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In some cases, oral or topical forms are used, depending on the treatment goal

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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

Orally administered glutathione is only sparingly absorbed due to its rapid hydrolysis by -glutamyltransferase present in intestinal mucosa, hepatocytes and cholangiocytes

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